Designing a safer chemical

Let’s get right into the meat of this topic. Here are some strategies for safer chemical design: Reduce absorption Use of toxicity generating mechanism Use of structure activity (toxicity) relationships Use of isosteric replacements Use of retrometabolic (‘soft’ chemical) design Identification of equally efficacious less toxic chemical substitutes of another class Elimination for the needContinue reading “Designing a safer chemical”


When a compound biodegrades, it returns to compounds found in nature complete its natural cycle. There are ways we can make this happen without waiting for it to happen naturally. We can either find the cause of resistance to biodegradation or enhance it. Understanding how biodegradation happens on the molecular level also helps. Molecular featuresContinue reading “Biodegradability”