Inherently Safer Plants – Part II

This blog post introduces some common terminologies related to safety, and then moves on to the intricacies of it. Hazard: A hazard is anything that may cause harm, such as chemicals, electricity, working from ladders, an open drawer, etc. Risk: The risk is the chance, high or low, that somebody could be harmed by these and other hazards, together … Continue reading Inherently Safer Plants – Part II

Inherently Safer Plants – Part I

"What you don't have, can't leak!" These are the words of Mr Trevor Kletz, ICI and LU. If you develop, operate and control a chemical process such that bad consequences are reduced, owing to different chemistry, chemicals, conditions or simplicity, wouldn't the safety of the plant be improved? Is this better than layers of protection? … Continue reading Inherently Safer Plants – Part I

Toxicity generating mechanisms

This post assumes you are well-versed with electrophiles and nucleophiles along with basics of Biology. If not, here are some links for you that can help. Video - DNA (Khan Academy) Nucleophiles, Electrophiles and Leaving Groups Toxicity generating mechanisms involving electrophiles: Electrophilic substitution or those metabolized to electrophilic species are capable of reacting covalently with … Continue reading Toxicity generating mechanisms