Isosteres are substances with similar molecular and electronic characteristics. They may not be structurally related, but they often have similar physical properties. They are chemical substances, atoms or substituents that possess nearly equal or similar molecular shape and volume, approximately the same distribution of electrons and exhibit similar chemical properties. Benzene and pyridine are classical examples of isosteres.
Can a carcinogenic molecule be made safe by knowing its isostere? Yes. Let’s look at an example.
Are all F isosteric substitutions safe?
Does it depend on the position?
Silicon as an isostere for Carbon
Si is the 2nd most abundant element on the planet. Naturally occurring Si-C bonds are unknown. Even if they were, such bonds would have immediately formed some other bond.
Silicon substitution in acetylcholine analogs
Acetylcholine is a neurotransmitter. A muscarinic receptor agonist is an agent that enhances the activity of muscarinic acetylcholine receptor.
Silane analogue of Polyethylene, Air stable
In the presence of water and/or soil, siloxanes hydrolyze to smaller oligomers and monomeric 1,1-dimethylsilanediol.
Mammals also rapidly oxidize silicon-hydrogen bond, whereas the carbons attached to silicon are metabolized much like simple hydrocarbons.
DDT, DDD & Silicon isosteres
DDT = dichlorodiphenyltrichloroethane
DDD = dichlorodiphenyldichloroethane
Why is DDT good? Millions of lives were saved against mosquitoes with the help of it. Why is DDT bad? It turned out to be an endocrine disruptor, genetoxic, persistent and exteremely hydrophobic chemical.
If you replace C with Si, no mortality of fish is observed at 50 mg/l. While with C in it, Fish LD50 is 3 mg/l.
2 thoughts on “Isosteres”
Is it possible to synthesis isosteres of DDT with Si.
Hi Dr. V. Babu, I’m sorry I do not have answer to your question. I learnt all this during my Masters and I’ve lost touch since then. I keep my notes online just in case someone needs it.